1: Reflex syncope Neuro-cardiogenic (vaso-vagal), carotid sinus syndrome, situational (micturition) 2: Cardiogenic Arrhythmias – Tachyarrhythmia: WPW (especially with Afib), Brugada, Long QT syndrome, – Bradyarrhythmia: Second degree AV Block Mobitz II, Third degree AV block, Sick sinus syndrome – Structural heart disease (HOCM, LVOT obstruction, Aortic stenosis, Intracardiac tumor: Myxoma 3: Orthostatic
NOACs
Antidote: Dabigatran = Idarucizumab (Praxabind) Idarucizumab for Dabigatran Reversal N Engl J Med 2015; 373:511-520 Factor Xa (Apixaban, Rivaroxaban) are POTENTIALLY reversible by Andexanet alfa (study was done in healthy human subjects, Andexanet reverses effect while infusion is running but rebounds on completion, further data will be available later) ANNEXA-4 trial N Engl J Med 2016;375:1131-41. Aripazine (PER977) is a medication currently on trial and can potentially reverse Factor Xa, dabigatran AND heparin, LMWH Use of PER977 to Reverse the Anticoagulant Effect of Edoxaban N Engl J … Continue reading “NOACs”
Brugada syndrome
Brugada Syndrome is an ECG abnormality with a high incidence of sudden death in patients with structurally normal hearts. It is due to a mutation in the cardiac sodium channel gene. This is often referred to as a sodium channelopathy. The 3 common types: TYPE I VERY SCARY – refer to arrhythmia team for ICD!
May-Thurner Syndrome
May-Thurner syndrome (MTS) is an anatomically and pathologically variable condition leading to venous outflow obstruction as a result of extrinsic venous compression in the iliocaval venous territory. With partial venous obstruction, the condition can be asymptomatic, but progression with symptoms related to chronic venous hypertension or venous occlusion can occur, with or without venous thrombosis. It is important to keep this condition in mind whenever a patient presents acutely with lower extremity swelling or deep vein thrombosis (DVT), particularly young … Continue reading “May-Thurner Syndrome”